Application

The sensitivity of Single Molecule Counting (SMC^®) technology gives the SMC^® Mouse IL-22 Discovery Immunoassay unparalleled performance in the quantification of IL-22 in mouse serum.

Used to detect/quantify:IL-22

Research Sub CategoryCytokines & Cytokine Receptors

Research CategoryInflammation & Immunology

Components

Assay BufferMouse IL-22 Coating AntibodyAssay Plate10X PBSBlocking BufferStandard DiluentMouse IL-22 Detection AntibodyMouse IL-22 StandardSMC^® Mouse IL-22 Immunoassay Kit Instructions10X Wash BufferBuffer CElution Buffer B

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

General description

Interleukin-22 (IL-22), also known as IL-10-related T-cell derived inducible factor (IL-TIF), is a member of the IL-10 cytokine family. Mainly produced by activated T-cells and natural killer cells, IL-22 binds to a receptor complex with two components, CRF2-4 and IL-22R. The signaling cascade is said to up-regulate pro-inflammatory cytokines and antimicrobial peptides, and induce production of acutephase reactants in liver and hepatoma cells. The biological function of IL-22 is associated with many inflammatory disorders, including Crohn’;s disease, inflammatory bowel disease, psoriasis, rheumatoid arthritis and ulcerative colitis. Thus, IL-22 remains an attractive therapeutic target because of its pro-inflammatory properties.

The SMC^® Mouse IL-22 Discovery Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format. Assay protocols are similar to existing sandwich ELISA methods with two key differences: 1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification. 2) The SMC^® immunoassay system detects analytes using Single Molecule Counting (SMC^®) technology.

Legal Information

SMC is a registered trademark of Singulex